Name | bendroflumethiazide |
Synonyms | Bendrofluazide BENDROFLUMETHIAZIDE bendroflumethiazide BENDROFLUMETHIAZIDE-D5 rac Bendroflumethiazide Bendroflumethiazide (200 mg) 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine,1,1 3-benzyl-3,4-dihydro-6-trifluoromethyl-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide 3-benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 3-(benzyl)-1,1-diketo-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxo-3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide |
CAS | 73-48-3 |
EINECS | 200-800-1 |
InChI | InChI=1/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23) |
Molecular Formula | C15H14F3N3O4S2 |
Molar Mass | 421.41 |
Density | 1.4711 (estimate) |
Melting Point | 205-207°C |
Boling Point | 602.1±65.0 °C(Predicted) |
Flash Point | 317.9°C |
Water Solubility | 40mg/L(room temperature) |
Solubility | Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent). |
Vapor Presure | 1.88E-14mmHg at 25°C |
Appearance | neat |
Color | Crystals from MeOH/CHCl3 |
pKa | pKa 8.53±0.05(H2O t=25 I=0.2) (Uncertain) |
Storage Condition | Refrigerator |
Refractive Index | 1.583 |
Physical and Chemical Properties | White crystalline powder. Melting Point 221-223 °c (226-227 °c). Insoluble in water, chloroform, benzene, ether, soluble in acetone, ethanol. |
WGK Germany | 2 |
RTECS | DK8225000 |
HS Code | 2935904000 |
Toxicity | LD50 oral in mouse: > 10gm/kg |
This product is 3-benzyl-6-trifluoromethyl-7-sulfonylamino-3, 4-dihydro-2h-1, 2, 4-benzothiadiazine-1, 1-dioxide. The content of C15H14F3N304S2 shall be between 98.0% and 102.0% calculated as dry product.
take 80mg of this product, precision weighing, put it in a 100ml measuring flask, add acetone to dissolve and dilute to the scale, shake well; Take 1ml for precision measurement, add 9.0ml of 1 mol/L hydrochloric acid solution, immediately add 0.10ml of 4% sodium nitrite solution, shake well, place for 1 minute, add 10% ml of 0.20 Ammonium sulfamate solution, shake well, place for 3 minutes, add 0.80 of dilute ethanol solution of 2% naphthyl ethylenediamine dihydrochloride, shake well, and place for 2 minutes (all the above operations are performed at 20°C), UV-visible spectrophotometry (General rule 0401), measured at a wavelength of 518nm absorbance, not greater than 0.11.
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
take this product about 0.2g, precision weighing, add N,N-dimethylformamide 40ml dissolved, add Azo violet indicator solution 3 drops, in nitrogen flow, with sodium methoxide titration solution (O. 1 mol/L) titration to the solution is exactly blue, and the result of the titration is corrected with a blank test. Each 1 ml of sodium methoxide titration solution (0.1 mol/L) corresponds to 21.07mg of C15H14F3N3O4S2.
diuretics.
sealed storage.
This product contains benzylfluorothiazide (C15H14F3N304S2) should be 90.0% to 110.0% of the label.
This product is white tablet.
take an appropriate amount of fine powder of this product (about 50mg equivalent to benzfluorothiazide), add 5ml of acetone, shake to dissolve benzfluorothiazide, filter, and evaporate the filtrate on a water bath, the residue was taken and the same reaction was shown according to the tests of identification (1) and (4) under the item of benzylfluorothiazide.
Content uniformity take 1 tablet of this product, put it in mortar, grind it finely, add an appropriate amount of 0.4% sodium hydroxide solution, grind it, and transfer it to a 25ml measuring flask in portions with 0.4% sodium hydroxide solution, fully shake to dissolve benzfluorothiazide, dilute to the scale with 0.4% sodium hydroxide solution, shake well, filter, precisely measure 2ml of filtrate, put it in a 25ml measuring flask, dilute to the scale with water, shake, determine the absorbance according to the method under the content determination item, and calculate the content, should comply with the provisions (General 0941).
Others shall be in accordance with the relevant provisions under the item tablets (General rule 0101).
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (equivalent to 15mg of benzfluorothiazide), and put it in a 100ml measuring flask, add 0.4% sodium hydroxide solution and shake intermittently for 10 minutes to dissolve benzfluorothiazide, dilute to the scale with 0.4% sodium hydroxide solution, shake well, filter, Take 5ml of filtrate and put it in 50ml measuring flask, dilute with water to scale, shake well, measure absorbance at the wavelength of 274nm by UV-Vis spectrophotometry (General rule 0401), add 0.Olmol/L sodium hydroxide solution is dissolved and diluted quantitatively to make a solution containing about 15ug per lml, and the absorbance is measured and calculated by the same method.
Same as benzylfluorothiazide.
5mg
sealed storage.